Indications
Agextrone-200 (Natural micronised porgestrone 200mg) softgel capsule is indicated for use in the prevention of endometrial hyperplasia in non-hysterectomized postmenopausal women who are receiving conjugated estrogens tablets. It is also indicated for use in secondary amenorrhea, as menopausal hormone therapy as an adjunct, prevention of recurrent miscarriage or treatment of threatened abortion.
    
Contraindications
Agextrone-200 (Natural micronised progestrone 200 mg) is contraindicated in known hypersensitivity to its ingredients, known / suspected pregnancy, thrombophlebitis, thromboembolic disorders, cerebral apoplexy, severe liver disease or dysfunction, known / suspected malignancy of breast or genital organs, undiagnosed vaginal bleeding, missed abortion and as a diagnostic test for pregnancy.

Precautions & Warnings 
Agextrone-200 (Natural micronised progrestrone 200 mg) must be advocated with due precaution in epilepsy, migraine, asthma, cardiac or renal dysfunction, and along with estrogens especially in diabetics.
    
Before instituting therapy with Agextrone-200, physical examination including especially of breast and genital organs, as well as Papanicolaou smear are advisable. In case of any vaginal bleeding whilst on progesterone (Agextrone-200) adequate diagnostic measures are indicated. Agextrone-200 must be promptly discontinued if any manifestations of thrombotic disorders occur. Sudden partial or complete vision loss, onset of proptosis, diplopia, or migraine necessitates withdrawal of Agextrone-200 if examination reveals papilledema or retinal vascular lesions.
    
Caution is advisable whilst driving a motor vehicle, or operating machinery during Agextrone-200 (Natural micrnised progrestrone 200) treatment. Agextrone-200 must be advocated during lactation only if strictly required. In pregnancy, it must be advised only if indicated. The safety and efficacy of natural progesterone in pediatric patients have not been established.
    
Drug Interactions
Agextrone-200 (Natural micronised progrestrone 200 mg) softgel capsules should be administered shift here with caution along estrogens.
    
Dosage & Administration
Prevention of Endometrial Hyperlasia: 1 Agextrone-200 Soft Gelatin Capsule as single daily evening dose for 12 days sequentially per 28 day cycle in postmenopausal women who are receiving daily conjugated estrogen tablets.
    
Secondary Amenorrhea: 2 Agextrone-200 Soft gelatin Capsules as a single daily evening dose for 10 days.
    
Presentations
Agextrone-200 Soft Gelatin Capsules: Blister Strip of 10s.