Indications
• Postoperative vomiting and vomiting during cancer chemotherapy
• Erosive or ulcerative GERD
• Dyspepsia
• Healing of duodenal ulcers
• Zollinger Ellison Syndrome
• Gastroparesis
• Healing of Duodenal Ulcers
• Treatment of Pathological Hypersecretory Conditions, Including Zollinger-Ellison Syndrome
• Irritable bowel syndrome
• Chronic Gastritis

Contraindications
Rabaze-LS (Rabeprazole & Levosulpiride) is hypersensitivity to any ingredient in the formulation. The drug should be used with caution in elderly people, children less than 14 years of age, Parkinson disease, and severe renal or hepatic insufficiency.
The drug should be used cautiously in pregnancy (only when it is expected to benefit the mother more than the possibility of risking the fetus).
The drug is known to be secreted in breast milk, so, its use should be restricted in breastfeeding women. 

Drug Interactions
The effects on gastric motility can be antagonized by anti-cholinergic drugs, narcotics and opioid analgesics, that is, if administered together, Levosulpiride's gastroprokinetic efficacy can be decreased.
Association with psycho pharmaceutical drugs requires special precautions and monitoring to avoid undesired and unexpected effects because of interactions. High doses can produce hyperprolactinemia, therefore special control during treatment is advised.
Rabeprazole produces a profound increase in gastric pH and may affect drugs whose absorption is pH dependant, such as ketoconazole and digoxin. Concomitant administration decreases ketoconazole levels by 33% and increases digoxin trough levels by up to 22%.

Warning & Precautions
Levosulpiride must not be used when stimulation of GI motility can be hazardous, for example, in presence of GI hemorrhages, mechanical obstructions or perforations.
It is recommended to be cautious when administering Levosulpiride altogether with alcohol intake, since it can produce an increase in the sedative effects of alcohol.
Levosulpiride can cause somnolence or sedation and dyskinesia in some patients; if some of these symptoms appear, avoid driving a vehicle or machinery.
Special caution is recommended in case of administering Levosulpiride together with psychopharmaceutical drugs, since an increase of undesired effects may occur. 

Dosage 
One RABAZE-LS daily on an empty stomach, or as directed by Physician.

Presentation
RABAZE-LS: Alu Alu of 10s