Indications & Usage
Pazenta-40 (Pantoprazole 40 mg) is advocated for the treatment o
• Peptic ulcers,
• NSAID-induced gastroduodenal damage, 
• Reflux esophagitis, 
• Hypersecretory states like Zollinger-Ellison syndrome 
• Pneumonitis. 
• Severe reflux esophagitis or in severe peptic ulcers.
  
Contraindications
Pazenta-40 (Pantoprazole 40 mg) should be used during pregnancy and lactation only if the potential benefit justifies the probable risks involved. Safety and efficacy of Pazenta-40 ingredients in children have not been established.
 Symptomatic response to pantoprazole does not preclude the presence of gastric malignancy. Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with pantoprazole. 
         
 Adverse Reactions
The most common adverse reactions reported with pantoprazole are anxiety, arthralgia, asthenia, back pain, bronchitis, chest pain, constipation, increased cough, dizziness, dyspepsia, dyspnea, flu syndrome, gastroenteritis, gastrointestinal disorders, hyperlipemia, hypertonia, infection, liver function tests abnormalities (SGPT increased), migraine, nausea, neck pain, pain, pharyngitis, rhinitis, sinusitis, upper respiratory tract infection, urinary frequency, urinary tract infection.

Drug Interaction
Since pantoprazole (in Pazenta-40) inhibits gastric acid secretion, it could interfere with absorption of drugs where gastric pH is an important determinant of bioavailability like ketoconazole, ampicillin esters.

Dosage & Administration
Usual Adult Dose for Gastroesophageal Reflux Disease
Recommended dose: 40 mg IV once a day, given over at least 2 minutes OR over 15 minutes. Duration of therapy: 7 to 10 days
Usual Adult Dose for Zollinger-Ellison Syndrome
• Initial dose: 80 mg IV every 12 hours, given over at least 2 minutes OR over 15 minutes
• Maintenance dose: 80 mg IV every 8 to 12 hours, given over at least 2 minutes OR over 15 minutes
• Maximum dose: 240 mg/day
• Maximum duration of therapy: 6 days

Presentation
Pazenta-40: 10 mL vail with 10 mL Sterile Sodium Chloride Injection IP