Indications & Usage
Pazenta-40 (Pantoprazole 40 mg) is advocated for the treatment o
• Peptic ulcers,
• NSAID-induced gastroduodenal damage, 
• Reflux esophagitis, 
• Hypersecretory states like Zollinger-Ellison syndrome 
• Pneumonitis. 
• Severe reflux esophagitis or in severe peptic ulcers.
  
Contraindications
Pazenta-40 (Pantoprazole 40 mg) should be used during pregnancy and lactation only if the potential benefit justifies the probable risks involved. Safety and efficacy of Pazenta-40 ingredients in children have not been established.

Symptomatic response to pantoprazole does not preclude the presence of gastric malignancy. Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with pantoprazole. 
         
Adverse Reactions
The most common adverse reactions reported with pantoprazole are anxiety, arthralgia, asthenia, back pain, bronchitis, chest pain, constipation, increased cough, dizziness, dyspepsia, dyspnea, flu syndrome, gastroenteritis, gastrointestinal disorders, hyperlipemia, hypertonia, infection, liver function tests abnormalities (SGPT increased), migraine, nausea, neck pain, pain, pharyngitis, rhinitis, sinusitis, upper respiratory tract infection, urinary frequency, urinary tract infection.

Drug Interaction
Since pantoprazole (in Pazenta-40) inhibits gastric acid secretion, it could interfere with absorption of drugs where gastric pH is an important determinant of bioavailability like ketoconazole, ampicillin esters.

Dosage & Administration
Adults:
One Pazenta-40 Tablet once daily for upto 8 weeks, or as prescribed by the physician.

Zollinger - Ellison Syndrome:  One Pazenta-40 Tablet twice daily or as prescribed by the physician. Maximum 240 mg pantoprazole daily in divided doses
Prevention of Aspiration Pneumonitis: One Pazenta-40 Tablet in the night before surgery and a second dose of one Pazenta-40 Tablet on the morning prior to surgery, or as prescribed.
Maintenance Therapy: One Pazenta-40 Tablet once daily to prevent recurrence in patients with reflux esophagitis or severe peptic ulcers, or as prescribed by the physician

Presentation
Pazenta-40: Alu Alu of 10s