Indications & Usage
• Meningitis
• Pneumonia 
• Typhoid
• PID
• Salpingitis
• Bacterial meningitis & Intraabdominal infections like peritonitis, liver abscess.
         

Contraindications
AGEX-TZ should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics. Caution in patients with a history of GI disease, especially colitis. Discontinue treatment in patients who develop signs/symptoms suggestive of gallbladder disease.
         
         
Precautions & Warnings
Its safety in human pregnancy has not been established. Therefore it should not be used in pregnancy unless absolutely indicated. Only minimal amount of Ceftriaxone is excreted in breast milk, so Mother-receiving Ceftriaxone should not breast-feed. In severe renal impairment accompanied by hepatic insufficiency, dosage reduction is required.
         
         
Adverse Reaction
Superinfection; anaphylaxis; diarrhoea; local reactions; blood dyscrasias; rash, fever, pruritus; elevated transaminases and alkaline phosphatase. GI effects; pseudomembranous colitis; hematologic effects; hypersensitivity reactions; CNS disturbances; hypertension; chest pain; edema; moniliasis; rhinitis; dyspnea; hypotension; ileus; syncope; local Injections site reactions; rigors.
         
Potentially Fatal: Pseudomembranous colitis; nephrotoxicity
         
         
Drug Interactions
• Potentially Fatal: Disulfiram-like reaction with alcohol. 
• Nephrotoxicity with aminoglycosides & furosemide.
         
         
Dosage & Administration
Adult

1000/125 – 2000/250 mg IV & IM, once a day or equally divided as twice daily

For uncomplicated gonococcal infections 250 mg once daily.

For surgical prophylaxis 1000-125mg1/2 to 2 before surgery IV & IM single dose.
         
Children

50/75 mg/kg (in ceftriaxone) IV & IM, every 12 hrs, with max dose is 2 gm in terms of ceftriaxone.

For meningitis100 mg/kg on 1st day and thereafter 80 mg/kg/day once daily (in terms of ceftriaxone) IV & IM with max dose is 4 gm.
         
         
Presentation
AGEX-TZ 1125:  supplied with 5ml sterile water for injection I.P.