Therapeutic Indications & Usage

AGIFIX-LB 100 Tablet is indicated for the treatment of infections caused by susceptible bacteria: 
• Upper respiratory tract infections, such as pharyngitis, sinusitis, otitis media, tonsillitis. 
• Lower respiratory tract infections, such as acute bronchitis and acute exacerbation of chronic bronchitis. 
• Uncomplicated urinary tract infections. 
• Uncomplicated gonorrhea.
         

Contraindications
AGIFIX-LB 100 Tablet is not advocated for those with a history of hypersensitivity to beta-lactams, e.g. penicillins and cephalosporins.
         
         
Precautions & Warnings
AGIFIX-LB 100 should be advocated with caution in presence of renal impairment or GI disease, particularly colitis. Prolonged use of AGIFIX could result in overgrowth of non-susceptible organisms. If superinfections occur (usually involving Aerobacter, Pseudomonas or Candida spp), AGIFIX should be discontinued and/or appropriate therapy instituted.

Periodic assessment of hematopoietic function is advisable during prolonged AGIFIX therapy. AGIFIX is not ideally meant for pregnant lady or lactating mother; however, it could be only if strictly necessary. Nursing discontinuation temporarily must be considered whilst taking AGIFIX. Safety and efficacy of cefixime in children less than 6 months old have not been established.

AGIFIX must be coadministered with carbamazepine, warfarin and other anticoagulants.
         
         
Adverse Reactions
The most frequent adverse effect is gastrointestinal (GI) complaints, and diarrhea incidence is 16%. Other side effects include hypersensitivity reactions, liver / renal dysfunction, headaches, dizziness, seizures, hematopoietic changes, genital pruritus, vaginitis, candidiasis.
         
         
Drug Interaction
Elevated carbamazepine levels occur when cefixime AGIFIX is coadministered. When given with warfarin / anticoagulants, the prothrombin time is elevated. Probenecid can decrease its clearance, whilst cholestyramine diminishes absorption of paracetamol when coadministered.
         
         
Recommended Dosage & Administration
Adults
Susceptible infections: 2 AGIFIX-LB 100 DT bid or as prescribed.
         
Uncomplicated cervical / urethral gonococcal infections: 2 AGIFIX-LB 100 Tabs, or as prescribed.
         
Children 
<50 kg: 8 mg/kg/day of AGIFIX Suspension / AGIFIX 50 / 100 DT either as single dose or in two divided doses. >50 kg:
         
         
Presentation
AGIFIX-LB 100: Alu Alu of 10s.