Indications
Uncomplicated P. falciparum malaria
Resistant P. vivax infections
Mixed, alarial infections

Contraindications
Hypersensitivity to artemether, lumefantrine, or any ingredient in the formulations.

Precautions & Warnings

QT interval prolongation reported. Do not use in patients with congenital long QT syndrome, clinical conditions known to prolong the QTc interval (e.g., symptomatic cardiac arrhythmias, clinically important bradycardia, severe cardiac disease), family history of congenital long QT syndrome or sudden death, or in those with electrolyte abnormalities (e.g., hypokalemia, hypomagnesemia) Do not use in those receiving treatment with class IA or III antiarrhythmic agents, antipsychotics (e.g., pimozide, ziprasidone), antidepressants, certain anti-infectives (e.g., macrolides, fluoroquinolones, imidazole- or triazole-derivative antifungal agents), cisapride (available in the US only under a limited-use protocol), or drugs known to be CYP2D6 substrates with cardiac effects

Drug Interactions

Concomitant use with certain drugs requires particular caution (e.g., other antimalarial drugs, antiretroviral agents).

Dosage

Adults:>16 years of age and weighing ?35 kg: 4 tablets as initial dose, 4 tablets 8 hours after the initial dose, and then 4 tablets twice daily (morning and evening) for the next two days .

Presentations

Agither-L Tablets: Alu Alu of 6s