MRP : 198/Strip of 10s
AGECLAV® 375 (Amoxicillin 250 mg & Clavulanic Acid 125 mg) Tablets is indicated for the treatment of infections caused by amoxicillin-resistant organisms producing beta-lactamases sensitive to clavulanic acid: Upper Respiratory Tract Infections (UTI), such as sinusitis, recurrent otitis media, and tonsillitis; Lower Respiratory Tract Infections (RTI), such as bronchitis (caused by amoxicillin-resistant beta-lactamases producing Escherichia coli, Hemophilus influenzae and Hemophilus para-influenzae), and bronchopneumonia; Genitourinary Tract Infections (GTI), such as cystitis, urethritis, and pyelonephritis; Skin and soft tissue infections.
AGECLAV® 375 (Amoxicillin 250 mg & Clavulanic Acid 125 mg) Tablets is also effective in the treatment of infections caused by amoxicillin-sensitive organisms at the appropriate amoxycillin dosage since in this situation the clavulanic acid component does not contribute to the therapeutic effect.
AGECLAV® 375 (Amoxicillin 250 mg & Clavulanic Acid 125 mg) Tablets is not advocated for those with a history of hypersensitivity to beta-lactams, e.g. penicillins and cephalosporins. AGECLAV® 375 (Amoxicillin 250 mg & Clavulanic Acid 125 mg) Tablets is also contraindicated in those with previous history of amoxicillin-clavulanic acid-associated jaundice / hepatic dysfunction.
AGECLAV® 375 (Amoxicillin 250 mg & Clavulanic Acid 125 mg) Tablets should be avoided if infectious mononucleosis is suspected since the occurrence of a morbilliform rash has been associated with this condition following the use of amoxicillin. AGECLAV® 375 (Amoxicillin 250 mg & Clavulanic Acid 125 mg) Tablets should not be used in renal failure when glomerular filtration rate is less than 30 ml/minute.
Precautions & Warnings
AGECLAV® 375 (Amoxicillin 250 mg & Clavulanic Acid 125 mg) Tablets should be advocated with caution in presence of hepatic dysfunction or renal impairment. Since AGECLAV® 375 (Amoxicillin 250 mg & Clavulanic Acid 125 mg) Tablet contains amoxicillin, an aminopenicillin, it is not the treatment of choice in patients presenting with sore throat or pharyngitis because of the possibility that the underlying cause is infectious mononucleosis, in the presence of which there is a high incidence of rash if Amoxicillin is used.
Periodic assessment of organ system functions, including renal, hepatic and hematopoietic function, is advisable during prolonged AGECLAV® 375 therapy. AGECLAV is not ideally meant for pregnant lady or lactating mother; however, it could be advocated only if strictly necessary. If superinfections occur (usually involving Aerobacter, Pseudomonas or Candida spp), AGECLAV® 375 should be discontinued and/or appropriate therapy needs to be instituted. AGECLAV® 375 (Amoxicillin 250 mg & Clavulanic Acid 125 mg) Tablets must be co-administered with caution along with probenecid and allupurinol.
Since both the 250-mg and 500-mg (amoxicillin) tablets of AGECLAV® 375 contain the same amount of clavulanic acid (125 mg, as the potassium salt), two 250-mg amoxicillin containing tablets of AGECLAV® 375 are not equivalent to one 500-mg (amoxicillin) tablet of AGECLAV® 625; therefore, two AGECLAV® 375 tablets should not be substituted for one tablet of AGECLAV® 625.
The most frequently reported adverse effects with Amoxicillin Clavulanic Acid (AGECLAV) are indigestion, diarrhea, nausea, vomiting, abdominal pain, skin rashes, urticaria and erythema multiforme, vaginitis, oral thrush, abnormal taste, headache, dizziness, tiredness and hot flushes. Other side effects attributable to amoxicillin (AGECLAV) include hypersensitivity reactions, other gastrointestinal reactions including superficial tooth discoloration, hepatitis, cholestatic jaundice, hematologic changes and central nervous system effects including convulsions.
Probenecid decreases the renal tubular secretion of amoxicillin, but does not affect Clavulanic Acid excretion. The combined administration of allopurinol and ampicillin substantially increases the incidence of skin rashes and AGECLAV® 375 (Amoxicillin 250 mg & Clavulanic Acid 125 mg) Tablets must be cautiously co-administered with allupurinol.
AGECLAV® 375 Tablets
Mild-to-Moderate Infections: 1 AGECLAV® 375 tid or as prescribed.
Glomerular filtration rate of 10-30 ml/min: 1 AGECLAV® 375 / 625 BID depending upon the severity of infection.
Hemodialysis: 1 AGECLAV® 375/ 625 OD depending upon the severity of infection. Or as prescribed.
AGECLAV® 375 Tablets: ALU ALU of 10s