<p><strong>Indications</strong></p>

<p>AGIFIX-200 from Agex Laboratories is indicated for the treatment of infections caused by susceptible bacteria:</p>

<ul>
	<li>Upper respiratory tract infections, such as pharyngitis, sinusitis, otitis media, tonsillitis.</li>
	<li>Lower respiratory tract infections, such as acute bronchitis and acute exacerbation of chronic bronchitis.</li>
	<li>Uncomplicated urinary tract infections.</li>
	<li>Uncomplicated gonorrhea.</li>
</ul>

<p><strong>Contraindications</strong></p>

<p>AGIFIX-200 from Agex Laboratories is not advocated for those with a history of hypersensitivity to beta-lactams, e.g. penicillins and cephalosporins.</p>

<p><strong>Precautions &amp; Warnings</strong></p>

<p>AGIFIX-200 Tablets should be advocated with caution in presence of renal impairment or GI disease, particularly colitis. Prolonged use of AGIFIX-200 Tablets could result in overgrowth of non-susceptible organisms. If superinfections occur (usually involving Aerobacter, Pseudomonas or Candida spp), AGIFIX-200 Tablets should be discontinued and/or appropriate therapy instituted.</p>

<p>Periodic assessment of hematopoietic function is advisable during prolonged AGIFIX therapy. AGIFIX is not ideally meant for pregnant lady or lactating mother; however, it could be only if strictly necessary. Nursing discontinuation temporarily must be considered whilst taking AGIFIX. Safety and efficacy of cefixime in children less than 6 months old have not been established.</p>

<p>AGIFIX-200 must be coadministered with carbamazepine, warfarin and other anticoagulants.</p>

<p><strong>Adverse Reactions</strong></p>

<p>The most frequent adverse effect is gastrointestinal (GI) complaints, and diarrhea incidence is 16%. Other side effects include hypersensitivity reactions, liver / renal dysfunction, headaches, dizziness, seizures, hematopoietic changes, genital pruritus, vaginitis, candidiasis.</p>

<p><strong>Drug Interaction</strong></p>

<p>Elevated carbamazepine levels occur when cefixime (AGIFIX) is coadministered. When given with warfarin / anticoagulants, the prothrombin time is elevated. Probenecid can decrease its clearance, whilst cholestyramine diminishes absorption of paracetamol when coadministered.</p>

<p><strong>Recommended Dosage &amp; Administration</strong></p>

<p>Adults Susceptible infections: 1 AGIFIX 200 Tab or 2 AGIFIX Tabs OD, or as prescribed. Uncomplicated cervical / urethral gonococcal infections: 2 AGIFIX Tabs, or as prescribed.</p>

<p><strong>Presentation</strong></p>

<p>AGIFIX-200 Tablets: Alu Alu strips of 10s.</p>
