<p><strong>Therapeutic Indications &amp; Usage</strong></p>

<p>AGIFIX-50 (Cefixime 50 mg) Dry Syrup from Agex Laboratories is indicated for the treatment of infections caused by susceptible bacteria:<br />
&bull; Upper respiratory tract infections, such as pharyngitis, sinusitis, otitis media, tonsillitis.<br />
&bull; Lower respiratory tract infections, such as acute bronchitis and acute exacerbation of chronic bronchitis.<br />
&bull; Uncomplicated urinary tract infections.<br />
&bull; Uncomplicated gonorrhea.</p>

<p><strong>Contraindications</strong></p>

<p>AGIFIX-50 (Cefixime-50 mg) Dry Syrup is not advocated for those with a history of hypersensitivity to beta-lactams, e.g. penicillins and cephalosporins.</p>

<p><strong>Precautions &amp; Warnings</strong></p>

<p>AGIFIX-50 (Cefixime-50 mg) Dry Syrup should be advocated with caution in presence of renal impairment or GI disease, particularly colitis. Prolonged use of AGIFIX-50 could result in overgrowth of non-susceptible organisms. If superinfections occur (usually involving Aerobacter, Pseudomonas or Candida spp), AGIFIX-50 should be discontinued and/or appropriate therapy instituted.</p>

<p>Periodic assessment of hematopoietic function is advisable during prolonged AGIFIX therapy. Safety and efficacy of cefixime in children less than 6 months old have not been established.</p>

<p>AGIFIX-50 (Cefixime 50 mg) Dry Syrup must be coadministered with carbamazepine, warfarin and other anticoagulants.</p>

<p><strong>Adverse Reactions</strong></p>

<p>The most frequent adverse effect is gastrointestinal (GI) complaints, and diarrhea incidence is 16%. Other side effects include hypersensitivity reactions, liver / renal dysfunction, headaches, dizziness, seizures, hematopoietic changes, genital pruritus, vaginitis, candidiasis.</p>

<p><strong>Drug Interaction</strong></p>

<p>Elevated carbamazepine levels occur when cefixime AGIFIX is coadministered. When given with warfarin / anticoagulants, the prothrombin time is elevated. Probenecid can decrease its clearance, whilst cholestyramine diminishes absorption of paracetamol when coadministered.</p>

<p><strong>Recommended Dosage &amp; Administration</strong></p>

<p>Children<br />
&lt;50 kg: 8 mg/kg/day of AGIFIX Suspension / AGIFIX 50 / 100 DT either as single dose or in two divided doses. &gt;50 kg:</p>

<p><strong>Presentation</strong><br />
AGIFIX 50: 30 ml bottle with measuring cap</p>
